Endocrine Abstracts

Marked secular trends in obesity prevalence are apparent throughout childhood, and this is leading to more adolescent girls presenting with clinical features of PCOS, including acne, hirsutism and menstrual irregularity. These girls typically also have central obesity and relatively early menarche (onset of first menstrual period).Certain overweight and obese girls may be particularly prone to developing PCOS features. Several studies have identified a r...

Objectives: To assess current clinical practice in children aged 0–5.99 years with Type I Diabetes Mellitus (T1DM).Methods: All paediatric diabetes centres (n=17) within a single UK region were asked to provide retrospective data for the year ending 01/12/07. 15 (88%) centres responded and provided data for each child on presentation, initial and current insulin regimens. Outcome measures were HbA1c, and acute hospital admissions post-diagnos...

Background: GH replacement during the childhood-adult transition period is important for somatic maturation. The aim of the study was to explore the factors influencing IGF1 response to GH during transition.Methods: KIMS (Pfizer International Metabolic Study) database in UK was interrogated, and 98 patients (55 male, median age 20.7 years (15.7–25.8)) with childhood-onset GH deficiency (Co-GHD), who were started on adult dose of GH during transition...